Estra-1,3,5(10)-trien-17-one,3-hydroxy-7-Methyl-, (7a)-
Almestrone
CAS: 10448-96-1
Molecular Formula: C19H24O2
Estra-1,3,5(10)-trien-17-one,3-hydroxy-7-Methyl-, (7a)- - Names and Identifiers
| Name | Almestrone |
| Synonyms | U 24704 SR 16279 NSC 134712 Almestrone 7alpha-Methylestrone 3-hydroxy-7-methylestra-1,3,5(10)-trien-17-one 3-Hydroxy-7a-methylestra-1,3,5(10)-trien-17-one 3-Hydroxy-7α-methylestra-1,3,5(10)-trien-17-one 3-Hydroxy-7alpha-methylestra-1,3,5(10)-trien-17-one (7alpha)-3-hydroxy-7-methylestra-1,3,5(10)-trien-17-one Estra-1,3,5(10)-trien-17-one,3-hydroxy-7-Methyl-, (7a)- (7R,8R,9S,13S,14S)-3-hydroxy-7,13-dimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one |
| CAS | 10448-96-1 |
| InChI | InChI=1/C19H24O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h3-4,10-11,15-16,18,20H,5-9H2,1-2H3 |
Estra-1,3,5(10)-trien-17-one,3-hydroxy-7-Methyl-, (7a)- - Physico-chemical Properties
| Molecular Formula | C19H24O2 |
| Molar Mass | 284.39 |
| Density | 1.127±0.06 g/cm3(Predicted) |
| Melting Point | 231-233 °C |
| Boling Point | 448.7±45.0 °C(Predicted) |
| Flash Point | 191.2°C |
| Vapor Presure | 1.14E-08mmHg at 25°C |
| pKa | 10.25±0.60(Predicted) |
| Refractive Index | 1.57 |
Estra-1,3,5(10)-trien-17-one,3-hydroxy-7-Methyl-, (7a)- - Introduction
Ameestrone (also known as a nonsteroidal antiestrogen) is a chemical compound with antiestrogenic activity. It is an organic compound with a chemical formula of C20H19NO2 and a molecular weight of 297.37g/mol.
The main properties of Ameestrone include high stability and anti-estrogenic effects. It acts as a non-steroidal antiestrogen that inhibits the action of estrogen by interfering with the binding of the Estrolane receptor (estrogen receptor). Because of its anti-estrogen activity, it can be used to treat some diseases that rely on estrogen growth, such as breast cancer, endometriosis, etc.
Ameestrone has various preparation methods, and the common methods include chemical synthesis and biological transformation. The method of chemical synthesis can be through acetophenone as raw material through ketone reduction, ketone acidification, esterification and other reactions to obtain almeestrone. The method of bioconversion is the metabolic transformation of a suitable substrate by a microbial strain to obtain Ameestrone.
For safety information, Ameestrone is generally prescribed for clinical use. In general, it is relatively safe in appropriate dosage, but it is still necessary to pay attention to potential side effects and contraindications during use. Common side effects include breast discomfort, menstrual irregularities, and dizziness. In addition, the use of Ameestrone is prohibited during pregnancy and should be used in consultation with a professional doctor. For special groups such as lactating women, children, etc., also need to be used carefully, and under the guidance of a doctor.
The main properties of Ameestrone include high stability and anti-estrogenic effects. It acts as a non-steroidal antiestrogen that inhibits the action of estrogen by interfering with the binding of the Estrolane receptor (estrogen receptor). Because of its anti-estrogen activity, it can be used to treat some diseases that rely on estrogen growth, such as breast cancer, endometriosis, etc.
Ameestrone has various preparation methods, and the common methods include chemical synthesis and biological transformation. The method of chemical synthesis can be through acetophenone as raw material through ketone reduction, ketone acidification, esterification and other reactions to obtain almeestrone. The method of bioconversion is the metabolic transformation of a suitable substrate by a microbial strain to obtain Ameestrone.
For safety information, Ameestrone is generally prescribed for clinical use. In general, it is relatively safe in appropriate dosage, but it is still necessary to pay attention to potential side effects and contraindications during use. Common side effects include breast discomfort, menstrual irregularities, and dizziness. In addition, the use of Ameestrone is prohibited during pregnancy and should be used in consultation with a professional doctor. For special groups such as lactating women, children, etc., also need to be used carefully, and under the guidance of a doctor.
Last Update：2024-04-10 22:29:15
